بررسی مقایسه‌ای علایم بالینی و یافته‌های پاراکلینیکی بیماران کووید-19 بستری در شهر یاسوج بر حسب نتیجه‌ی تست RT-PCR
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ذاکر سعیدی نژاد
فرزاد مظلومی راد
آناهید پوزش
محمد امین قطعی
نادر دبیری
فرزاد مظلومی راد
آناهید پوزش
محمد امین قطعی
نادر دبیری
چکیده
مقدمه: کووید-19 خطرناک‌ترین ویروس خانواده‌ی کرونا ویریده (Coronaviridae) محسوب می‌شود. کووید-19 با روش (Reverse transcription polymerase chain reaction) RT-PCR از نمونه‌های سواب بینی و اروفارنکس تشخیص داده می‌شود. مطالعه‌ی حاضر با هدف مقایسه‌ی ویژگی‌های بالینی، پاراکلینیکی و دموگرافیک بیماران کووید-19 بستری در بیمارستان شهید جلیل شهر یاسوج در دو گروه RT-PCR+ و RT-PCR- انجام شد.
شیوه‌ی مطالعه: مطالعه‌ی حاضر، مطالعه‌ای توصیفی گذشته‌نگر می‌باشد که با بررسی پرونده‌ی 330 بیمار به روش نمونه‌گیری تصادفی انجام شد.
یافته‌ها: در اکثر ویژگی‌های دموگرافیک از جمله سن و جنس تفاوت معنی‌داری بین دو گروه RT-PCR+ و RT-PCR- وجود نداشت. ارتباط معنی‌داری بین نتیجه‌ی تست RT-PCR و علائم بالینی تب، سردرد، اختلال در حس بویایی، اختلال در حس چشایی، کابوس و سنگینی در قفسه‌ی سینه مشاهده شد (0/05 > p value). ارتباط معنی‌داری بین نتایج RT-PCR و تعداد نوتروفیل‌ها، BUN و پلاکت‌ها از لحاظ آماری مشاهده شد (0/05 > p value).
نتیجه‌گیری: به کمک برخی از علایم بالینی همچون از دست دادن حس چشایی، بویایی و تب می‌توان در مراحل اولیه‌ی بیماری که تست RT-PCR بیمار به علت بار ویروسی کم منفی است، برای تشخیص بیماری کووید-19 استفاده کرد.
کلمات کلیدی: کووید-19؛ واکنش زنجیره‌ای پلیمراز ترانس کریپتاز معکوس
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استناد به مقاله
سعیدی نژادذ., مظلومی رادف., پوزشآ., قطعیم. ا., & دبیرین. (2023). بررسی مقایسه‌ای علایم بالینی و یافته‌های پاراکلینیکی بیماران کووید-19 بستری در شهر یاسوج بر حسب نتیجه‌ی تست RT-PCR. مجله دانشکده پزشکی زابل, 55-63. Retrieved از http://jzms.ir/index.php/JZMS/article/view/392
نوع مقاله
مقاله پژوهشی
مراجع
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27. Karimi F, Vaezi AA, Qorbani M, Moghadasi F, Gelsfid SH, Maghoul A, et al. Clinical and laboratory findings in COVID-19 adult hospitalized patients from Alborz province/Iran: comparison of rRT-PCR positive and negative. BMC Infect Dis 2021; 21(1): 256.
2. Zhang T, Wu Q, Zhang Z. Probable pangolin origin of SARS-CoV-2 associated with the COVID-19 outbreak. Curr Biol 2020; 30(7): 1346-51.e2.
3. Ge H, Wang X, Yuan X, Xiao G, Wang C, Deng T, et al. The epidemiology and clinical information about COVID-19. Eur J Clin Microbiol Infect Dis 2020; 39(6): 1011-9.
4. Carstens EB. Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2009). Arch Virol 2010; 155(1): 133-46.
5. Hofmann H, Pyrc K, Van Der Hoek L, Geier M, Berkhout B, Pöhlmann S. Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry. Proc Natl Acad Sci U S A 2005; 102(22): 7988-93.
6. Vlasak R, Luytjes W, Spaan W, Palese P. Human and bovine coronaviruses recognize sialic acid-containing receptors similar to those of influenza C viruses. Proc Natl Acad Sci U S A 1988; 85(12): 4526-9.
7. Sardar R, Satish D, Birla S, Gupta D. Comparative analyses of SAR-CoV2 genomes from different geographical locations and other coronavirus family genomes reveals unique features potentially consequential to host-virus interaction and pathogenesis. Heliyon 2020; 6(9): e04658.
8. Chan JFW, Lau SK, To KKW, Cheng VCC, Woo PCY, Yuen KY. Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease. Clin Microbiol Rev 2015; 28(2): 465-522.
9. Yan Y, Chang L, Wang L. Laboratory testing of SARS‐CoV, MERS‐CoV, and SARS‐CoV‐2 (2019‐nCoV): Current status, challenges, and countermeasures. Rev Med Virol 2020; 30(3): e2106.
10. Almeida JD, Tyrrell DA. The morphology of three previously uncharacterized human respiratory viruses that grow in organ culture. J Gen Virol 1967; 1(2): 175-8.
11. Andersen KG, Rambaut A, Lipkin WI, Holmes EC, Garry RF. The proximal origin of SARS-CoV-2. Nat Med 2020; 26(4): 450-2.
12. Zhang W, Du RH, Li B, Zheng XS, Yang XL, Hu B, et al. Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. Emerg Microbes Infect 2020; 9(1): 386-9.
13. .Long QX, Tang XJ, Shi QL, Li Q, Deng HJ, Yuan J, et al. Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections. Nat Med 2020; 26(8): 1200-4.
14. Yan Y, Chang L, Wang L. Laboratory testing of SARS‐CoV, MERS‐CoV, and SARS‐CoV‐2 (2019‐nCoV): Current status, challenges, and countermeasures. Rev Med Virol 2020; 30(3): e2106.
15. Loeffelholz MJ, Tang YW. Laboratory diagnosis of emerging human coronavirus infections–the state of the art. Emerg Microbes Infect 2020; 9(1): 747-56.
16. Caruso D, Zerunian M, Polici M, Pucciarelli F, Polidori T, Rucci C, et al. Chest CT features of COVID-19 in Rome, Italy. Radiology 2020: 296(2): E79-85.
17. Ghasemian R, Alizadeh-Navaei R, Boskabadi J, Rezaei Kalantari K. Clinical features and paraclinical findings of patients died of covid-19 in a referral hospital in sari, iran, february 2020-may 2020 [in Persian]. J Mazandaran Univ Med Sci 2021; 31(198): 119-32.
18. Keshavarz F, Ghalamfarsa F, Javdansirat S, Hasanzadeh S, Azizi A, Sabz G, et al. Patients with Covid 19 have significantly reduced CH50 activity. Virusdisease 2021; 32(4): 681-9.
19. Pan F, Ye T, Sun P, Gui S, Liang B, Li L, et al. Time course of lung changes at chest CT during recovery from coronavirus disease 2019 (COVID-19). Radiology 2020; 295(3): 715-21.
20. Chen ZH, Li YJ, Wang XJ, Ye YF, Wu BL, Zhang Y, et al. Chest CT of COVID-19 in patients with a negative first RT-PCR test: Comparison with patients with a positive first RT-PCR test. Medicine (Baltimore); 99(26): e20837.
21. Li C, Su Q, Liu J, Chen L, Li Y, Tian X, Li W. Comparison of clinical and serological features of RT-PCR positive and negative COVID-19 patients. J Int Med Res 2021; 49(2): 300060520972658.
22. Wang Z, Chen X, Lu Y, Chen F, Zhang W. Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment. Biosci Trends 2020; 14(1): 64-68.
23. Alfadda AA, AlKhowaiter M, Alotaibi N, Alayed K, Alzahrani M, Binkhamis K, et al. Clinical and biochemical characteristics and outcomes of suspected COVID-19 hospitalized patients: RT-PCR swab positive and negative comparison. J Infect Public Health 2021; 14(11): 1623-29.
24. Özkarafakılı MA, Özkurt H, Bardakçı Mİ, Akıllı IK, Yanç U, Altuntaş Y, et al. Comparison of chest computed tomography findings of RT-PCR negative and RT-PCR positive cases in COVID-19 patients. Clin Imaging 2022; 82: 7-12.
25. Nasrollahzadeh Sabet M, Heidari MF, Khanalipour M, Ghaffari SA, Jafari Ashiani M, Biglari S, et al. Evaluation of the conformity between chest CT scan results with molecular diagnosis test in patients with COVID-19 [in Persian]. J Arak Uni Med Sci 2020; 23(5): 766-73.
26. Song S, Wu F, Liu Y, Jiang H, Xiong F, Guo X, et al. Correlation between chest CT findings and clinical features of 211 COVID-19 suspected patients in Wuhan, China. Open Forum Infect Dis 2020; 7(6): ofaa171.
27. Karimi F, Vaezi AA, Qorbani M, Moghadasi F, Gelsfid SH, Maghoul A, et al. Clinical and laboratory findings in COVID-19 adult hospitalized patients from Alborz province/Iran: comparison of rRT-PCR positive and negative. BMC Infect Dis 2021; 21(1): 256.